Modulation of chemosensory receptors and ligands associated therewith

The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of...

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Bibliographische Detailangaben
Hauptverfasser:	RINNOVA MARKETA, YAMAMOTO JEFFREY, LIU HAITIAN, DARMOHUSODO VINCENT, FINE RICHARD, HAMMAKER JEFFREY ROBERT, TANG XIAO-QING, ZHANG HONG, FOTSING JOSEPH R, KIMMICH RACHEL D. A, LI XIAODONG, CHEN QING, KANG XINSHAN, TACHDJIAN CATHERINE, SERVANT GUY, KARANEWSKY DONALD S, ZLOTNIK ALBERT, ADAMSKI-WERNER SARA, PETROVIC GORAN, ZHANG FENG, KLEBANSKY BORIS
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Beschreibung
Zusammenfassung:	The present invention includes methods for identifying modifiers of chemosensory receptors and their ligands, e.g., by determining whether a test entity is suitable to interact with one or more interacting sites within the Venus flytrap domains of the chemosensory receptors, and modifiers capable of modulating chemosensory receptors and their ligands. The present invention also includes modifiers of chemosensory receptors and their ligands having Formula (I), its subgenus, and specific compounds. Furthermore, the present invention includes ingestible compositions comprising the modifiers of chemosensory receptors and their ligands and methods of using the modifiers of chemosensory receptors and their ligands to enhance the sweet taste of an ingestible composition or treat a condition associated with a chemosensory receptor. In addition, the present invention include processes for preparing the modifiers of chemosensory receptors and their ligands.