c-Met modulators and methods of use

The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit...

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Hauptverfasser:	CHAN DIVA SZE-MING, TAKEUCHI CRAIG STACY, MANN LARRY W, KHOURY RICHARD GEORGE, PARKS JASON JEVIOUS, BANNEN LYNNE CANNE, WANG YONG, DALRYMPLE LISA ESTHER, JAMMALAMADAKA VASU, FORSYTH TIMOTHY PATRICK, MANN GRACE, NUSS JOHN M, LEAHY JAMES WILLIAM, CHEN JEFF, MAC MORRISON B, HUYNH TAI PHAT, XU WIE
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.