4-piperidinyl compounds for use as tankyrase inhibitors

The present invention provides for compounds of formula (I): wherein R1-R4 and n are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the t...

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Bibliographische Detailangaben
Hauptverfasser: TOURE BAKARY-BARRY, CHEN CHRISTINE HIU-TUNG, DIPIETRO LUCIEN V, CHIN DONOVAN NOEL, FAN JIANMEI, PALERMO MARK G, SHULTZ MICHAEL DAVID
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention provides for compounds of formula (I): wherein R1-R4 and n are defined herein. The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.