Binding molecules for human factor VIII and factor VIII-like proteins

It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KELLEY BRIAN D, DEETZ JEFFREY S, YU JINAN, POTTER M. DANIEL, BOOTH JAMES E
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.