Network devices with multiple fully isolated and independently resettable direct memory access channels and methods thereof

A method, computer readable medium, and system independently managing network applications within a network traffic management device communicating with networked clients and servers include monitoring with a network device a plurality of applications communicating over a plurality of direct memory access (DMA) channels established across a bus. The network device receives a request from a first application communicating over a first DMA channel in the plurality of DMA channels to restart the first DMA channel. In response to the request, the first DMA channel is disabled with the network device while allowing other executing applications in the plurality of applications to continue to communicate over other DMA channels in the plurality of DMA channels. A state of the first DMA channel is cleared independently from other DMA channels in the plurality of DMA channels, and communications for the first application over the first DMA channel are resumed with the network device.