Substantially coumarin-free extract of cinnamon and its production method

A pharmaceutical composition comprising a substantially coumarin-free extract derived from cinnamon. Its production method including some steps: grinding the raw material, extracting raw material from previous step by maceration using a first solvent to obtain crude extract of Cinnamomum burmanii, f...

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Bibliographische Detailangaben
Hauptverfasser: YULIANI VERONIKA, TJANDRAWINATA RAYMOND R, WULAN DEASY DIAH DWI RETNO, SINAMBELA JAMES M
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:A pharmaceutical composition comprising a substantially coumarin-free extract derived from cinnamon. Its production method including some steps: grinding the raw material, extracting raw material from previous step by maceration using a first solvent to obtain crude extract of Cinnamomum burmanii, fractionating the extracted raw material from previous step through liquid-liquid extraction using a second solvent, wherein the second solvent is immiscible with the first solvent to obtain substantially coumarin-free extract, and optionally drying the substantially coumarin-free extract. The pharmaceutical composition comprising the substantially coumarin-free extract as a single component or in a combination with suitable pharmaceutical excipient(s) to produce a pharmaceutical composition that is safe to be consumed daily and in long-term use.