Antibodies to TGF-beta

The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGF ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralize TGF 1, TGF 2 and TGF 3, so-called "pan-spe...

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Bibliographische Detailangaben
Hauptverfasser:	HOLGATE ROBERT G, JERMUTUS LUTZ U, LEDBETTER STEVEN R, DUNCAN ALEXANDER R, BUCHANAN CATRIONA L, FINCH DONNA K, HART CELIA PATRICIA
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to antibody molecules, in particular antibody molecules that bind Transforming Growth Factor beta (TGF ), and uses thereof. More particularly, the invention relates to antibody molecules that bind and preferably neutralize TGF 1, TGF 2 and TGF 3, so-called "pan-specific" antibody molecules, and uses of such antibody molecules. Preferred embodiments within the present invention are antibody molecules, whether whole antibody (e.g. IgG, such as IgG1 or IgG4) or antibody fragments (e.g. scFv, Fab, dAb).