Sulfonamide derivatives

The present invention relates to sulfonamide derivatives, of formula (I): or a pharmaceutically acceptable salts thereof, wherein X, Z, R1a, R1b, R2, R3, R4 and R5 are as defined in the description, and to their use in medicine, to compositions containing them, to processes for their preparation and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: RAWSON DAVID JAMES, SWAIN NIGEL ALAN, STORER ROBERT IAN
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention relates to sulfonamide derivatives, of formula (I): or a pharmaceutically acceptable salts thereof, wherein X, Z, R1a, R1b, R2, R3, R4 and R5 are as defined in the description, and to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. The compounds of formula (I) are Nav1.7 inhibitors useful in the treatment of a wide range of disorders, particularly pain.