Compounds and methods of use
In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formul...
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| creator | NIKOLAKOPOULOS GEORGE NDUBAKU CHUDI COLMAN PETER DUDLEY DANETTE A WATSON KEITH GEOFFREY LESSENE GUILLAUME LAURENT SLEEBS BRAD EDMUND ELMORE STEVEN W BAELL JONATHAN BAYLDON FLYGARE JOHN A SOUERS ANDREW J CZABOTAR PETER FAIRBROTHER WAYNE J BUI CHINH THIEN SMITH BRIAN JOHN PETROS ANDREW M RYE CARL STEVEN |
| description | In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins. |
| format | Patent |
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In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150630&DB=EPODOC&CC=US&NR=9067928B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20150630&DB=EPODOC&CC=US&NR=9067928B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NIKOLAKOPOULOS GEORGE</creatorcontrib><creatorcontrib>NDUBAKU CHUDI</creatorcontrib><creatorcontrib>COLMAN PETER</creatorcontrib><creatorcontrib>DUDLEY DANETTE A</creatorcontrib><creatorcontrib>WATSON KEITH GEOFFREY</creatorcontrib><creatorcontrib>LESSENE GUILLAUME LAURENT</creatorcontrib><creatorcontrib>SLEEBS BRAD EDMUND</creatorcontrib><creatorcontrib>ELMORE STEVEN W</creatorcontrib><creatorcontrib>BAELL JONATHAN BAYLDON</creatorcontrib><creatorcontrib>FLYGARE JOHN A</creatorcontrib><creatorcontrib>SOUERS ANDREW J</creatorcontrib><creatorcontrib>CZABOTAR PETER</creatorcontrib><creatorcontrib>FAIRBROTHER WAYNE J</creatorcontrib><creatorcontrib>BUI CHINH THIEN</creatorcontrib><creatorcontrib>SMITH BRIAN JOHN</creatorcontrib><creatorcontrib>PETROS ANDREW M</creatorcontrib><creatorcontrib>RYE CARL STEVEN</creatorcontrib><title>Compounds and methods of use</title><description>In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. 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In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | Compounds and methods of use |
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