Compounds and methods of use

Compounds and methods of use

In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formul...

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Hauptverfasser: NIKOLAKOPOULOS GEORGE, NDUBAKU CHUDI, COLMAN PETER, DUDLEY DANETTE A, WATSON KEITH GEOFFREY, LESSENE GUILLAUME LAURENT, SLEEBS BRAD EDMUND, ELMORE STEVEN W, BAELL JONATHAN BAYLDON, FLYGARE JOHN A, SOUERS ANDREW J, CZABOTAR PETER, FAIRBROTHER WAYNE J, BUI CHINH THIEN, SMITH BRIAN JOHN, PETROS ANDREW M, RYE CARL STEVEN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:In one aspect, the present invention provides for a compound of Formula I in which in Formula I, the variables X1, X2a, X2b, X2c, R1, B, L, E, A and the subscript n are as defined herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.