Process for forming amorphous atorvastatin

A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxida...

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Bibliographische Detailangaben
Hauptverfasser: ROSE PETER ROBERT, SHALAEV EVGENYI, QUALLICH GEORGE JOSEPH, DEBETTENCOURT, III ANTONE JOHN, ZIEGLER CARL BERNARD
Format: Patent
Sprache:eng
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Zusammenfassung:A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin.