Binder-drug conjugates (ADCs) and use thereof

The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the us...

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Bibliographische Detailangaben
Hauptverfasser:	BORKOWSKI SANDRA, BEIER RUDOLF, SCHUHMACHER JOACHIM, LERCHEN HANS-GEORG, HARRENGA AXEL, EL SHEIKH SHERIF, JÖRI EN HANNAH, GREVEN SIMONE, LINDEN LARS, STELTE-LUDWIG BEATRIX, BRUDER SANDRA, GOLFIER SVEN, WILLUDA JÖRG, HEISLER IRING, THIERAUCH KARL-HEINZ, MAHLERT CHRISTOPH, PETRUL HEIKE, KOPITZ CHARLOTTE CHRISTINE
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present application relates to new binder-drug conjugates (ADCs) of N,N-dialkylauristatins that are directed against the target C4.4a, to active metabolites of these ADCs, to processes for preparing these ADCs, to the use of these ADCs for treating and/or preventing illnesses, and also to the use of these ADCs for producing medicaments for treating and/or preventing illnesses, more particularly hyperproliferative and/or angiogenic diseases such as, for example, cancer diseases. Such treatments may be practiced as a monotherapy or else in combination with other medicaments or further therapeutic measures.