Stable cannabinoid compositions and methods for making and storing them

A composition comprising a high purity cannabinoid, an acid, and a pharmaceutically-acceptable solvent achieves room temperature stability for over 24 months. The acid improves the stability of the composition and the solvent enhances the solubility of the acid, thereby allowing the acid to have an...

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Bibliographische Detailangaben
Hauptverfasser:	HOGAN ROBERT, SILVERBERG LEE JONATHAN, ROSSI RONALD, SHAH RAMESH M
Format:	Patent
Sprache:	eng
Schlagworte:	APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILARCONTAINERS BOTTLES, JARS OR SIMILAR CONTAINERS CHEMISTRY CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OFBOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOTOTHERWISE PROVIDED FOR CONVEYING FUNNELS HANDLING THIN OR FILAMENTARY MATERIAL HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE LIQUID HANDLING MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGINGARTICLES OR MATERIALS MEDICAL OR VETERINARY SCIENCE METALLURGY OPENING CLOSED CONTAINERS OPENING, CLOSING ORGANIC CHEMISTRY PACKING PERFORMING OPERATIONS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES STORING TRANSPORTING UNPACKING
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Beschreibung
Zusammenfassung:	A composition comprising a high purity cannabinoid, an acid, and a pharmaceutically-acceptable solvent achieves room temperature stability for over 24 months. The acid improves the stability of the composition and the solvent enhances the solubility of the acid, thereby allowing the acid to have an improved stabilizing effect on the highly pure cannabinoid. Preferably, the solvent is an alcohol and, more preferably, the composition contains an oil. A method for making the composition includes combining the cannabinoid and the solvent and evaporating a portion of the solvent, along with adding an acid to the composition, before, during, or after the evaporating step. A method for making and storing the composition includes storing the composition in a manner adapted to maintain its stability. Pharmaceutical dosage forms include a formulated composition, such as having the oil. A method of treating a subject comprises administering to the subject the dosage form.