Monocyclic pyridine derivative

The present invention provides a novel compound having FGFR inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same. Specifically, the present invention provides a compound represented by the following formula (I) or a pharmaceutically...

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Bibliographische Detailangaben
Hauptverfasser: OKADA TOSHIMI, YAMANE YOSHINOBU, NAGAO SATOSHI, NAKATANI YUSUKE, KAROJI YUKI, OHASHI ISAO, FUNASAKA SETSUO, TANAKA KEIGO
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention provides a novel compound having FGFR inhibitory activity or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same. Specifically, the present invention provides a compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof: wherein n represents 0 to 2; A represents an arylene group or a heteroarylene group; G represents a single bond, an oxygen atom or -CH2-; E represents a nitrogen-containing non-aromatic heterocycle; R1 represents an alkoxy group or the like; R2 represents a hydrogen atom or the like; and R3 represents a hydrogen atom, an alkyl group, an alkoxy group or the like, with the proviso that when E represents an azetidine ring and R2 or R3 is present on a nitrogen atom on the azetidine ring, the R2 or R3 does not represent a hydrogen atom.