Cytotoxic compounds for treating cancer

Cytotoxic compounds for treating cancer

The cytotoxic compounds are gold(III) complexes of the type [(diaminocyclohexane)AuCl2]Cl, derived from sodium tetrachloroaurate(III) dihydrate NaAuCl4.2H2O. Specifically, the cytotoxic compounds are gold complexes of isomers of 1,2-diaminocyclohexane, namely cis-(±)-1,2-(diaminocyclohexane)AuCl3, t...

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Bibliographische Detailangaben
Hauptverfasser: ISAB ANVARHUSEIN ABDULKADIR, WAZEER MOHAMMED ISMAIL MOHAMMED, ALTUWAIJRI SALEH ABDULAZIZ, AL-JAROUDI SAID SALMAN
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The cytotoxic compounds are gold(III) complexes of the type [(diaminocyclohexane)AuCl2]Cl, derived from sodium tetrachloroaurate(III) dihydrate NaAuCl4.2H2O. Specifically, the cytotoxic compounds are gold complexes of isomers of 1,2-diaminocyclohexane, namely cis-(±)-1,2-(diaminocyclohexane)AuCl3, trans-(±)-1,2-(diaminocyclohexane)AuCl3 and S,S-(+)-1,2-(diaminocyclohexane)AuCl3. In order to treat cancer cells in a patient, such as human prostate cancer cells or human gastric cancer cells, an effective amount of the isomer of 1,2-(diaminocyclohexane)AuCl3 is administered to the cancer cells in the patient. The isomer of 1,2-(diaminocyclohexane)AuCl3 is preferably administered with a concentration ranging between about 10 μM and 20 μM.