Anti-ADDL antibodies and uses thereof

The present invention relates to antibodies that differentially recognize multi-dimensional conformations of A -derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods...

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Bibliographische Detailangaben
Hauptverfasser:	KINNEY GENE, STROHL WILLIAM R, BREESE ROBERT, SHUGHRUE PAUL, LAMBERT MARY P, KLEIN WILLIAM L, DODSON ELIZABETH CHEN, ACTON PAUL, VIOLA KIRSTEN, CHANG LEI, LIANG XIAOPING, BETT ANDREW J, AN ZHIQIANG
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to antibodies that differentially recognize multi-dimensional conformations of A -derived diffusible ligands, also known as ADDLs. The antibodies of the invention can distinguish between Alzheimer's Disease and control human brain extracts and are useful in methods of detecting ADDLs and diagnosing Alzheimer's Disease. The present antibodies also block binding of ADDLs to neurons, assembly of ADDLS, and tau phosphorylation and are there useful in methods for the preventing and treating diseases associated with soluble oligomers of amyloid 1-42.