Diaryl ether derivatives as notch sparing gamma secretase inhibitors

Diaryl ether derivatives as notch sparing gamma secretase inhibitors

The invention encompasses a novel class of diaryl ether derivatives which inhibit the processing of APP by the putative γ-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: WILLIAMS PETER D, REGER THOMAS, SILIPHAIVANH PHIENG, BROWN WILLIAM COLBY, BRUBAKER JASON, MILLER THOMAS, METHOT JOEY L, KELLEY ELIZABETH H, OTTE KARIN M, WISCOUNT CATHERINE M, FISCHER CHRISTIAN, HEIDEBRECHT RICHARD W, HENDRIX JOHN T, MACCOSS RACHEL N
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention encompasses a novel class of diaryl ether derivatives which inhibit the processing of APP by the putative γ-secretase while sparing Notch signaling pathway, and thus are useful in the treatment or prevention of Alzheimer's disease without the development of Notch inhibition mediated gastrointestinal issues. Pharmaceutical compositions and methods of use are also included.