Anti-rotation and removal resistant adapter for use with a syringe

An adapter and syringe assembly is described in this application which includes a syringe and an adapter for anti-rotation, removal resistant connection to the syringe. The syringe has a body defining a fluid reservoir, a plunger assembly including a plunger head dimensioned to be slidably received within the reservoir, a fluid outlet, and a first coupling member. The adapter has a body portion defining a fluid channel, a collar portion, and a second coupling member configured to engage the first coupling member to secure the adapter to the syringe. The syringe includes at least one rib and a surface of the collar includes at least one protrusion. The at least one rib and the at least one protrusion are configured and positioned to interact to facilitate attachment of the adapter to the syringe but to resist detachment of the oral dose tip adapter from the syringe. The body portion of the adapter may define an oral dose tip or a needle hub assembly.