3′-azido purine nucleotide prodrugs for treatment of viral infections

3′-azido purine nucleotide prodrugs for treatment of viral infections

The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, and HBV, in human patients or other animal hosts. The compounds are 3′-azido-2′,3′-dideoxy purine monophosphates, and pharmaceutically acceptable, salts, prodrugs...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SLUIS-CREMER NICOLAS PAUL, CHO JONG HYUN, MELLORS JOHN W, COATS STEVEN J, ZHANG HONGWANG, HERMAN BRIAN DAVID, SCHINAZI RAYMOND F, ZHOU LONGHU, WHITAKER RICHARD ANTHONY
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
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Beschreibung
Zusammenfassung:The present invention is directed to compounds, compositions and methods for treating or preventing viral infections, in particular, HIV, and HBV, in human patients or other animal hosts. The compounds are 3′-azido-2′,3′-dideoxy purine monophosphates, and pharmaceutically acceptable, salts, prodrugs, and other derivatives thereof. In particular, the compounds show potent antiviral activity against HIV-1 and HBV.