Therapeutic antibodies binding IL12R 1

The present invention relates to antibodies that specifically bind to IL12R 1, the non-signal transducing chain of the heterodimeric IL12 receptor (together with IL12R 2 chain) as well as IL23 receptor (together with IL23Rα chain). The invention more specifically relates to specific antibodies that...

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Bibliographische Detailangaben
Hauptverfasser:	DELLA DUCATA DANIELA, CARBALLIDO HERRERA JOSE M, BARDROFF MICHAEL, HEUSSER CHRISTOPH, JAEGER UTE, SCHWAERZLER CHRISTOPH
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to antibodies that specifically bind to IL12R 1, the non-signal transducing chain of the heterodimeric IL12 receptor (together with IL12R 2 chain) as well as IL23 receptor (together with IL23Rα chain). The invention more specifically relates to specific antibodies that are IL12 and IL23 receptor antagonists capable of inhibiting IL12/IL18 induced IFNγ production of T cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting IFNγ production, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders.