Nicotinic acetylcholine receptor modulators

The disclosure provides compounds capable of selectively or non-selectively modulating nicotinic acetylcholine receptors. The compounds, compositions, and methods described herein are useful, for example, in treating patients suffering from various medical conditions including pain, chemical addicti...

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Bibliographische Detailangaben
Hauptverfasser: KHROYAN TALINE, POLGAR WILLMA E, ZAVERI NURULAIN T, JIANG FAMING, OLSEN CRIS M, TOLL LAWRENCE R
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The disclosure provides compounds capable of selectively or non-selectively modulating nicotinic acetylcholine receptors. The compounds, compositions, and methods described herein are useful, for example, in treating patients suffering from various medical conditions including pain, chemical addictions, Parkinson's disease, Alzheimer's disease, and neurodegenerative disorders. In one embodiment, the compounds comprise a 7- to 11-membered azabicyclo ring.