Substituted pyrazolo[1,5-a]pyrimidines as cyclin dependent kinase inhibitors

In its many embodiments, the present invention provides a method of inhibiting one or more cyclin dependent kinases in a patient comprising administering to said patient a therapeutically effective amount of at least one pyrazolo[1,5-a]pyrimidine compound or a pharmaceutical composition comprising s...

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Hauptverfasser:	FISCHMANN THIERRY O, HOBBS DOUGLAS WALSH, BANNERJI RAJAT, PARUCH KAMIL, PARADKAR VIDYADHAR M, GIRIJAVALLABHAN VIYYOOR M, MADISON VINCENT S, GUZI TIMOTHY J, MALLAMS ALAN, PARK HAENGSOON, RIVERA JOCELYN, DILLARD LAWRENCE W, JAMES RAY ANTHONY, DOLL RONALD J, KIRSCHMEIER PAUL, DWYER MICHAEL P, TRAN VINH D, CHAN TIN-YAU, HE ZHENMIN, KEERTIKAR KARTIK M, ALVAREZ CARMEN S
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	In its many embodiments, the present invention provides a method of inhibiting one or more cyclin dependent kinases in a patient comprising administering to said patient a therapeutically effective amount of at least one pyrazolo[1,5-a]pyrimidine compound or a pharmaceutical composition comprising such compound, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions. An example pyrazolo[1,5-a]pyrimidine compound useful in the present invention is shown below: