Benzoxazepines as inhibitors of PI3K/mTOR and methods of their use and manufacture

Benzoxazepines as inhibitors of PI3K/mTOR and methods of their use and manufacture

The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.

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Bibliographische Detailangaben
Hauptverfasser: NG STEPHANIE, DEFINA STEVEN CHARLES, KIM ANGIE INYOUNG, ZAHARIA CRISTIANA A, HARRIS JASON R, BOWLES OWEN JOSEPH, JOSHI ANAGHA, JACKSON-UGUETO EILEEN E, MANALO JEAN-CLAIRE LIMUN, ANAND NEEL KUMAR, BUSSENIUS JOERG, TSANG TSZE H, BLAZEY CHARLES M, TSUHAKO AMY LEW, CURTIS JEFFRY KIMO, PETO CSABA J, RICE KENNETH D, BUHR CHRIS ALLEN, DUBENKO LARISA, MA SUNGHOON
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention is directed to Compounds of Formula I: and pharmaceutically acceptable salts or solvates thereof, as well as methods of making and using the compounds.