Substituted benz-azoles and methods of their use as inhibitors of RAF kinase

Substituted benz-azoles and methods of their use as inhibitors of RAF kinase

New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disor...

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Bibliographische Detailangaben
Hauptverfasser: SUNG LEONARD, AMIRI PAYMAN, HANSEN TERESA, MCBRIDE CHRISTOPHER, LEVINE BARRY HASKELL, RAMURTHY SAVITHRI, SHAFER CYNTHIA M, SUBRAMANIAN SHARADHA, POON DANIEL J, RENHOWE PAUL A, FANTL WENDY
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.