Formulations which stabilize and inhibit precipitation of immunogenic compositions

The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions....

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Bibliographische Detailangaben
Hauptverfasser: HAN HANYOUNG, CHEN YING, JIN ZHAOWEI, MALONE RONALD, KHANDKE LAKSHMI, YANG CINDY XUDONG, LOOK JEE LOON, SEID, JR. ROBERT C
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present invention addresses an ongoing need in the art to improve the stability of immunogenic compositions such as polysaccharide-protein conjugates and protein immunogens. The invention broadly relates to novel formulations which stabilize and inhibit precipitation of immunogenic compositions. More particularly, the invention described hereinafter, addresses a need in the art for formulations which stabilize and inhibit particulate formation (e.g., aggregation, precipitation) of immunogenic compositions which are processed, developed, formulated, manufactured and/or stored in container means such as fermentors, bioreactors, vials, flasks, bags, syringes, rubber stoppers, tubing and the like.