Method of production of 9-cis-retinoic acid

Method of production of 9-cis-retinoic acid

Improved method of production of 9-(Z)-retinoic acid, in which a) a beta-formyl-crotonic acid C1-C10 alkyl or phenyl ester is reacted with an isolated 9-(Z)-C15-triarylphosphonium salt by the Wittig reaction in the presence of a base to the corresponding 9-(Z)-retinoic acid ester; which b) is then s...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: KNOPP MONIKA, KUEBEL ERWIN, STANEK MICHAEL, ESSL STEFAN
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Improved method of production of 9-(Z)-retinoic acid, in which a) a beta-formyl-crotonic acid C1-C10 alkyl or phenyl ester is reacted with an isolated 9-(Z)-C15-triarylphosphonium salt by the Wittig reaction in the presence of a base to the corresponding 9-(Z)-retinoic acid ester; which b) is then saponified with a base to the corresponding 9-(Z)-retinoic acid carboxylate and then, following protonation with an acid, the desired 9-(Z)-retinoic acid is obtained, and improved method for the enrichment and isolation of the 9-(Z)-C15-triarylphosphonium salt.