Protein kinase modulators and method of use

The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions...

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Bibliographische Detailangaben
Hauptverfasser:	ZHU XIAOTIAN, OLIVIERI PHILLIP R, CEE VICTOR J, XI NING, HODOUS BRIAN L, JOHNSON REBECCA E, GEUNS-MEYER STEPHANIE D, TEMPEST PAUL, PATEL VINOD F, ROMERO KARINA, NGUYEN HANH NHO, DEAK HOLLY L, KIM JOSEPH L, CHENG YUAN, BELLON STEVEN, ALBRECHT BRIAN K, CHAFFEE STUART C
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other proliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.