Antibody and use thereof

An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid beta fibrils or monomeric amyloid beta-proteins. According to the present invention, an antibody is provided that has a higher reactiv...

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Bibliographische Detailangaben
Hauptverfasser:	HOSHI MINAKO, NODA MUNEHIRO, HORIE SATOSHI, SATO MICHIO, NAITO KOJI, HORII HAJIME, IDENO SHOJI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	An antibody provided by the present invention has a low reactivity with amyloid precursor proteins, and has a higher reactivity with amylospheroids than with amyloid beta fibrils or monomeric amyloid beta-proteins. According to the present invention, an antibody is provided that has a higher reactivity with amylospheroids than with amyloid precursor proteins, and has any one or more of the following properties: (i) a higher activity with amylospheroids than with amyloid beta fibrils; (ii) a higher reactivity with amylospheroids than with monomeric amyloid beta-proteins; and (iii) an activity of inhibiting neuronal cell death induced by amylospheroids.