17-beta HSD1 and STS inhibitors

17-beta HSD1 and STS inhibitors

Substituted steroid compounds which represent selective inhibitors of 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1) and, in addition, which may represent inhibitors of the steroid sulfatase, salts thereof, pharmaceutical preparations containing these compounds, and a process for the prepa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MESSINGER JOSEF, THOLE HEINRICH-HUBERT, KOSKIMIES PASI, HUSEN BETTINA, WESKE MICHAEL, PIRKKALA LILA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
STEROIDS
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Beschreibung
Zusammenfassung:Substituted steroid compounds which represent selective inhibitors of 17beta-hydroxysteroid dehydrogenase type I (17beta-HSD1) and, in addition, which may represent inhibitors of the steroid sulfatase, salts thereof, pharmaceutical preparations containing these compounds, and a process for the preparation of these compounds. Also disclosed is a therapeutic method of using such substituted steroid compounds, particularly in the treatment, inhibition, prophylaxis or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of 17beta-hydroxysteroid dehydrogenase type I and/or steroid sulfatase enzymes and/or requiring lowering of the endogenous 17beta-estradiol concentration.