3-phenylpyrazolo[5,1-b]thiazole compounds

A compound represented by the following formula (I), or salt thereof exhibits excellent CRF receptor antagonism, and sufficient pharmacological activity, safety and pharmacokinetic properties as a drug. wherein R1 represents the formula -A11-A12; R2 represents tetrahydrofurylmethyl, tetrahydropyrany...

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Hauptverfasser: SHIBATA HISASHI, SHIKATA KODO, HASHIZUME MINAKO, TAKAHASHI YOSHINORI, INOMATA AKIRA, TERAUCHI TARO, TAKEDA KUNITOSHI, SHIN KOGYOKU
Format: Patent
Sprache:eng
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Zusammenfassung:A compound represented by the following formula (I), or salt thereof exhibits excellent CRF receptor antagonism, and sufficient pharmacological activity, safety and pharmacokinetic properties as a drug. wherein R1 represents the formula -A11-A12; R2 represents tetrahydrofurylmethyl, tetrahydropyranylmethyl or tetrahydropyranyl; A11 represents a single bond, methylene or 1,2-ethylene; A12 represents C1-6 alkyl, C3-6 cycloalkyl or C3-6 cycloalkyl having methyl; R3 represents methoxy, cyano, cyclobutyloxymethyl, methoxymethyl or ethoxymethyl; and R4 represents methoxy or chlorine.