5-lipoxygenase-activating protein (FLAP) inhibitors

5-lipoxygenase-activating protein (FLAP) inhibitors

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HUTCHINSON JOHN H, PRASIT PETPIBOON PEPPI, STOCK NICHOLAS SIMON, EVANS JILLIAN F, HADDACH MUSTAPHA, STEARNS BRIAN ANDREW, MORAN MARK, ZUNIC JASMINE ELEANOR, ROPPE JEFFREY ROGER, LI YIWEI, ARRUDA JEANNIE M
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.