Altered peptide ligand derived from HSP60 and pharmaceutical compositions

Altered peptide ligand derived from HSP60 and pharmaceutical compositions

Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of...

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Bibliographische Detailangaben
Hauptverfasser: HORTA MARIA DEL CARMEN DOMINGUEZ, DIAZ CARELIA COSME, MERINO GARCIA NELSON J, PALOMARES GABRIEL RAMON PADRON, BONACHEA ARIEL VAZQUEZ, ALBA JOSE SUAREZ, HERNANDEZ GARCIA ARIADNA, BETANCOURT ARIANA BARBERA, PEREZ NORAILYS LORENZO, LOPEZ MARIN NELIA, CORDOVA VIVIAN MORERA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.