Small interfering RNAs and methods for prevention, inhibition and/or treatment of malignant progression of breast cancer
The invention found that overexpression and activation of α9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of α9-nAChR so as to inhibit breast cancer. Therefore, the invention provides small interfering RNAs (siRNAs)...
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| creator | WANG YING-JAN CHEN LIING LEE CHIA-HWA CHENG TZUUN CHANG YU-JIA HO YUAN-SOON CHEN CHING-SHYANG HUANG CHING-SHUI WEI PO-LI WU CHIH-HSIUNG TU SHIH-HSIN CHU JAN-SHOW TAM KA-WAI |
| description | The invention found that overexpression and activation of α9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of α9-nAChR so as to inhibit breast cancer. Therefore, the invention provides small interfering RNAs (siRNAs) for inhibiting expression of α9-nAChR so as to inhibit breast cancer, methods to prevent/inhibit/treat malignant progression of nicotine-derived-compound-induced breast cancer and method of determining malignant level of such breast cancer. |
| format | Patent |
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| subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS |
| title | Small interfering RNAs and methods for prevention, inhibition and/or treatment of malignant progression of breast cancer |
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