Small interfering RNAs and methods for prevention, inhibition and/or treatment of malignant progression of breast cancer

Small interfering RNAs and methods for prevention, inhibition and/or treatment of malignant progression of breast cancer

The invention found that overexpression and activation of α9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of α9-nAChR so as to inhibit breast cancer. Therefore, the invention provides small interfering RNAs (siRNAs)...

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Bibliographische Detailangaben
Hauptverfasser: WANG YING-JAN, CHEN LIING, LEE CHIA-HWA, CHENG TZUUN, CHANG YU-JIA, HO YUAN-SOON, CHEN CHING-SHYANG, HUANG CHING-SHUI, WEI PO-LI, WU CHIH-HSIUNG, TU SHIH-HSIN, CHU JAN-SHOW, TAM KA-WAI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
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Beschreibung
Zusammenfassung:The invention found that overexpression and activation of α9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of α9-nAChR so as to inhibit breast cancer. Therefore, the invention provides small interfering RNAs (siRNAs) for inhibiting expression of α9-nAChR so as to inhibit breast cancer, methods to prevent/inhibit/treat malignant progression of nicotine-derived-compound-induced breast cancer and method of determining malignant level of such breast cancer.