Multimeric CD40 ligands, method for preparing same and use thereof for preparing drugs

A compound of formula (I) is described, wherein Y represents a macrocycle, the ring of which has 9 to 36 atoms, and is functionalized by three amine or COOH functions; Rc represents a group of formula H-Xa-Xb-Xc-Xd-Xe-(Xf)i-, i represents 0 or 1, Xa is in particular lysine, arginine, or ornithine re...

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Hauptverfasser:	HOEBEKE JOHAN, WIECKOWSKI SEBASTIEN, CHALOIN OLIVIER, GUICHARD GILLES, FOURNEL SYLVIE VICTORINE LUCIENNE, TROUCHE NATHALIE
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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creator	HOEBEKE JOHAN WIECKOWSKI SEBASTIEN CHALOIN OLIVIER GUICHARD GILLES FOURNEL SYLVIE VICTORINE LUCIENNE TROUCHE NATHALIE
description	A compound of formula (I) is described, wherein Y represents a macrocycle, the ring of which has 9 to 36 atoms, and is functionalized by three amine or COOH functions; Rc represents a group of formula H-Xa-Xb-Xc-Xd-Xe-(Xf)i-, i represents 0 or 1, Xa is in particular lysine, arginine, or ornithine residues, Xb is in particular glycine, asparagine, L-proline or D-proline residues, Xc and Xd are in particular tyrosine, phenylalanine or 3-nitrotyrosine residues, Xe and Xf are in particular amino acid residues: NH2-(CH2)n-COOH, n ranging from 1 to 10, or NH2-(CH2-CH2-O)m-CH2CH2COOH, m ranging from 3 to 6, provided that at least one of the amino acid residues Xa, Xb, Xc and Xd is different from the corresponding amino acid in the sequence of the natural CD40 143Lys-Gly-Tyr-Tyr146 fragment(SEQ ID NO: 1).
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subjects	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
title	Multimeric CD40 ligands, method for preparing same and use thereof for preparing drugs
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