Multimeric CD40 ligands, method for preparing same and use thereof for preparing drugs

Multimeric CD40 ligands, method for preparing same and use thereof for preparing drugs

A compound of formula (I) is described, wherein Y represents a macrocycle, the ring of which has 9 to 36 atoms, and is functionalized by three amine or COOH functions; Rc represents a group of formula H-Xa-Xb-Xc-Xd-Xe-(Xf)i-, i represents 0 or 1, Xa is in particular lysine, arginine, or ornithine re...

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Hauptverfasser: HOEBEKE JOHAN, WIECKOWSKI SEBASTIEN, CHALOIN OLIVIER, GUICHARD GILLES, FOURNEL SYLVIE VICTORINE LUCIENNE, TROUCHE NATHALIE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:A compound of formula (I) is described, wherein Y represents a macrocycle, the ring of which has 9 to 36 atoms, and is functionalized by three amine or COOH functions; Rc represents a group of formula H-Xa-Xb-Xc-Xd-Xe-(Xf)i-, i represents 0 or 1, Xa is in particular lysine, arginine, or ornithine residues, Xb is in particular glycine, asparagine, L-proline or D-proline residues, Xc and Xd are in particular tyrosine, phenylalanine or 3-nitrotyrosine residues, Xe and Xf are in particular amino acid residues: NH2-(CH2)n-COOH, n ranging from 1 to 10, or NH2-(CH2-CH2-O)m-CH2CH2COOH, m ranging from 3 to 6, provided that at least one of the amino acid residues Xa, Xb, Xc and Xd is different from the corresponding amino acid in the sequence of the natural CD40 143Lys-Gly-Tyr-Tyr146 fragment(SEQ ID NO: 1).