HSA-free formulations of interferon-Beta

Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (IFN- ) and methods useful in their preparation are provided. The compositions comprise the IFN- solubilized in a low-ionic-strength formulation that maintains the composition at a pH of about 3.0 to about 5.0....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	CHEN BAO-LU, HORA MANINDER, SHIRLEY BRET A, BABUKA SUSAN, CHOE MINNA, TELLERS MELANIE
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (IFN- ) and methods useful in their preparation are provided. The compositions comprise the IFN- solubilized in a low-ionic-strength formulation that maintains the composition at a pH of about 3.0 to about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN- in pharmaceutical compositions, are provided.