Peptides and altered peptide ligands derived from HSP60 and pharmaceutical compositions

Peptides and altered peptide ligands derived from HSP60 and pharmaceutical compositions

Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: DOMINGUEZ HORTA MARIA DEL CARMEN, MERINO GARCIA NELSON J, PADRON PALOMARES GABRIEL RAMON, LORENZO PEREZ NORAILYS, HERNANDEZ GARCIA ARIADNA, MORERA CORDOVA VIVIAN, LOPEZ MARIN NELIA, BARBERA BETANCOURT ARIANA, VAZQUEZ BONACHEA ARIEL, COSME DIAZ CARELIA, SUAREZ ALBA JOSE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.