Heterocyclic compounds and methods of use

Heterocyclic compounds and methods of use

In one aspect, the present invention provides for a compound of Formula I in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compou...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: NIKOLAKOPOULOS GEORGE, HASVOLD LISA A, TAO ZHI-FU, NDUBAKU CHUDI, COLMAN PETER, DUDLEY DANETTE A, WANG LE, WATSON KEITH GEOFFREY, LESSENE GUILLAUME LAURENT, SLEEBS BRAD EDMUND, ELMORE STEVEN W, BAELL JONATHAN BAYLDON, FLYGARE JOHN A, DESHAYES KURT, SOUERS ANDREW J, CZABOTAR PETER, WANG XILU, FAIRBROTHER WAYNE J, BUI CHINH THIEN, SMITH BRIAN JOHN, PETROS ANDREW M
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In one aspect, the present invention provides for a compound of Formula I in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.