Metabolites and derivatives of ambrisentan

Metabolites and derivatives of ambrisentan

The invention relates to derivatives and metabolites of ambrisentan, including compounds of general Formula (I) or salts, hydrates, solvates, racemates, or optical isomers thereof, wherein R1 is -OH or -OCH3; R2 is -H, lower alkyl (e.g. C1-C4 alkyl) or glycosidyl; and R3 and R4 are independently -CH...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ULLRICH MARTINA, MELVIN, JR. LAWRENCE S, HEGE HANS-GUENTHER, WEYMANN JUERGEN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:The invention relates to derivatives and metabolites of ambrisentan, including compounds of general Formula (I) or salts, hydrates, solvates, racemates, or optical isomers thereof, wherein R1 is -OH or -OCH3; R2 is -H, lower alkyl (e.g. C1-C4 alkyl) or glycosidyl; and R3 and R4 are independently -CH3, -C(O)H or -CH2OR6, wherein R6 is -H or a hydrocarbyl group having 1 to 20 carbon atoms.