Self calibration of audio device

An audio device performs self calibration with respect to an audio source location when processing an audio signal frame determined likely to be dominated by the audio source. One or more conditions for sub-bands within the audio frame are evaluated to help identify whether the frame is dominated by the audio source. If the conditions meet a threshold value for a number of sub-bands within the frame, the audio signal may be identified as one dominated by the desired audio source and an audio source location coefficient may be adapted. Additionally, when the audio source location coefficient falls below a threshold value, (e.g., suggesting that one of two or more microphones is blocked), noise suppression is reduced or eliminated for the frame or frame sub-bands to prevent suppression of a desired audio source component along with the noise component.