Aroyl-piperidine derivatives and method of treating disorders induced by substance P

The invention relates to a method of administering N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(quinoloylamino)-piperidines of the formula wherein Y is N- or N(O)-, R is OH when Y is N- and R is H when Y is N(O)- and the ring A is unsubstituted or mono- or poly-substituted by substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, provided that when R is OH and Y is N- the ring A is not unsubstituted, for the treatment of disorders induced by substance P, such as: pain, migraines, anxiety, vomiting, schizophrenia, depression; motor disorders such as Parkinson's disease, inflammatory diseases such a rheumatoid arthritis, iritis and conjunctivitis, diseases of the respiratory organs such as asthma and chronic bronchitis, diseases of the gastrointestinal system such as ulcerative colitis and Crohn's disease, and hypertension.