ALDH-2 inhibitors in the treatment of addiction

Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.

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Bibliographische Detailangaben
Hauptverfasser:	ZABLOCKI JEFF, KALLA RAO, ABELMAN MATTHEW, PERRY THAO, YAO LINA, TAO GUOXIN, ELZEIN ELFATIH, KOBAYASHI TETSUYA, ORGAN MICHAEL, LI XIAOFEN, FAN PEIDONG, DIAMOND IVAN, JIANG ZHAN, AROLFO MARIA PIA, KEUNG WING MING, JIANG ROBERT, BILOKIN YAROSLAV
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Disclosed are novel isoflavone derivatives having the structure of Formula I which are useful as ALDH-2 inhibitors for treating mammals for dependence upon drugs of addiction, for example addiction to dopamine-producing agent such as cocaine, morphine, amphetamines, nicotine, and alcohol.