Nucleoside cyclic phosphoramidates for the treatment of RNA-dependent RNA viral infection

Nucleoside cyclic phosphoramidates for the treatment of RNA-dependent RNA viral infection

The present invention provides nucleoside cyclic phosphoramidates of formula (I), pharmaceutical compositions comprising the compounds of formula (I) and methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infect...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: NARJES FRANK, GARDELLI CRISTINA, PACINI BARBARA, DURETTE PHILIPPE L, MEPPEN MALTE
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SUGARS
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Beschreibung
Zusammenfassung:The present invention provides nucleoside cyclic phosphoramidates of formula (I), pharmaceutical compositions comprising the compounds of formula (I) and methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection using the compounds of formula (I).