6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors

Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asth...

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Hauptverfasser: ARNOLD LEE D, ZHANG TAO, CESARIO CARA, LAUFER RADOSLAW, NIGRO ANTHONY I, MULVIHILL MARK J, LI AN-HU, FOREMAN KENNETH, MULVIHILL KRISTEN MICHELLE, DONG HANQING, WYLE MICHAEL J, PANICKER BIJOY, HONDA AYAKO, COATE HEATHER, STEINIG AMO G, SUN YINGCHUAN, WENG QINGHUA, CREW ANDREW PHILIP, WERNER DOUGLAS S
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Sprache:eng
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Zusammenfassung:Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.