JAK-2 modulators and methods of use

This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibit...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	TAKEUCHI CRAIG STACY, JOHNSON HENRY WILLIAM BEECROFT, GALAN ADAM ANTONI, KEARNEY PATRICK, MANN GRACE, FORSYTH TIMOTHY, ZHOU PEIWEN, LEAHY JAMES W, CHEN JEFF, DU HONGWANG, HUYNH TAI PHAT, RIDGWAY BRIAN HUGH, LEE MATTHEW SANGYUP
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.