Antibodies to stromal cell-derived factor-1 polypeptides

Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vect...

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Bibliographische Detailangaben
Hauptverfasser: HESTIR KEVIN, CHU KETING, LEE ERNESTINE, WONG JUSTIN G. P, TSUI COLLINS AMY L, WILLIAMS LEWIS T
Format: Patent
Sprache:eng
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Zusammenfassung:Disclosed herein is a newly identified SDF-1 splice variant molecule, its polypeptide sequence, and the polynucleotides encoding the polypeptide sequence, and active fragments thereof. Also provided is a procedure for producing such polypeptides by recombinant techniques employing, for example, vectors and host cells. Also disclosed are methods for utilizing such polypeptides and modulators thereof for the treatment of diseases, including cancer, immune diseases, infectious diseases, and ischemic diseases.