System and method for image registration

Certain embodiments of the present invention provide for a system and method for performing medical image registration. Pixel and voxel correspondences are formulated as energy minimization problems and are optimized with graph cuts. The method includes processing a first set of data and a second set of data using a graph cuts algorithm to determine a minimum value of an energy function. The energy function has a data term and a smoothness term. The method also includes performing registration for the first set of data and the second set of data based on the data term and the smoothness term of the energy function. The system includes a computer system for performing medical image registration. The computer system comprises a processor and a memory in communication with the processor. The memory includes program code executable by the processor for executing a medical image registration algorithm.