Cytokine design

The present invention relates to novel methods for the design of proteins, in particular, cytokines. These methods allow the stabilisation of such cytokines, as well as modification of their selectivity/specificity for their cognate receptors. The invention also relates to various modified proteins...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	SZEGEZDI EVA E, SAMALI AFSHIN, TUR VICENTE R, SERRANO LUIS, VAN DER SLOOT ALBERT MARTINUS, QUAX WILHELMUS J, MULLALLY MARGARET M, COOL ROBBERT H, FERNANDEZ-BALLESTER GREGORIO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS
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Beschreibung
Zusammenfassung:	The present invention relates to novel methods for the design of proteins, in particular, cytokines. These methods allow the stabilisation of such cytokines, as well as modification of their selectivity/specificity for their cognate receptors. The invention also relates to various modified proteins that have been designed by the methods of the invention.