Substituted arylamine compounds and methods of treatment

Substituted arylamine compounds and methods of treatment

The invention relates to 5-HT6 receptor antagonists. Novel arylamine compounds and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with serotonin action, such as in treating obesity, and obesity...

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Bibliographische Detailangaben
Hauptverfasser: SHARADENDU ANURAG, NOIMAN SILVIA, ORBACH PINI, CHERUKU SRINIVASA RAO, WU LAURENCE, MARANTZ YAEL, LOBERA MERCEDES, SENDEROWITZ HANOCH, DHANOA DALE S, FICHMAN MERAV, SHACHAM SHARON, SAHA ASHIS, MELENDEZ ROSA, BECKER OREN, YU XIANG Y
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates to 5-HT6 receptor antagonists. Novel arylamine compounds and use of these compounds and their pharmaceutical compositions, e.g., in the treatment, modulation and/or prevention of physiological conditions associated with serotonin action, such as in treating obesity, and obesity-related disorders, e.g., cardiovascular disease, digestive disease, respiratory disease, cancer and type II diabetes; and psychological disorders such as schizophrenia, are disclosed.